Toxins + Dermal Fillers = Longer Lasting Results...

A simple technique has been found for for prolonging the effects of HA dermal fillers: using them together with botulinum toxin


Chemodenervation using botulinum neurotoxin-A (BoNT-A) can prolong the life of the HA fillers by reducing muscle activity in the treated area, according to a study by Dr Ismail Küçüker, recently reported in Plastic and Reconstructive Surgery.

For augmentation patients, the early degradation of HA fillers limits the duration of their cosmetic improvement. The extent of an improvement is affected not only by the properties of the HA fillers, but also by application of other forces, including contractile forces of neighbouring muscles. Using HA fillers in combination with muscle paralysing BoNT-A-best has been found to reduce this and evidence from several studies suggest that this chemodenervation procedure improves the clinical results of HA filler injection.

For this study, Dr Küçüker and colleagues studied rabbits’ ears—injecting a small amount of HA filler under the skin in front of each ear—knowing that this part of a the ear corresponds to the forehead region in humans-a common area for dermal filler treatment.

On one side, HA filler alone was used. On the other, HA was used with the muscle paralysis inducing BoNT-A. MRI scans three months later compared the amount of filler remaining on the two sides and confirmed that BoNT-A decreased the degradation rate of the HA fillers by 42%, plus remaining volume of HA filler was 50% greater on the side where BoNT-A was used. The difference was not only measurable, it was visible—supporting the clinical experience that BoNT-A injection provides longer-lasting outcomes in patients.

“This study showed that HA filler application in combination with BoNT-A significantly decreases the degradation process and increases the remaining volume at the end of the paralysed period,” Dr Küçüker and colleagues conclude.

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